ABG: Opioid effect

Clinical - Respiratory/Pulmonary

Opioid consumption produces a respiratory acidosis (accumulation of CO2). Chronic opioid users may excrete Cl- (classically thought of as “retaining bicarbonate” although in reality is is the loss of the strong anion that matters from a pH perspective, see the work of Kellum J re: strong ion difference and its relationship to pH) in an effort to compensate and will therefore exhibit an elevated serum [HCO3-].

For rules on expected compensation and additional information, see Acid Base link on this page.

Sources

    Acid Base

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Answered correctly

2012

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74%

Answered correctly

2009

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