Aldosterone: Regulation

Basic, Organ-Based and Clinical Sciences

• Released from zona glomerulosa of the adrenal glands 

• Responsible for long term control (days) of blood pressure and plasma osmolarity

o Kidneys alter total body sodium and water balance to restore blood pressure to normal

• Increased release

o ACTH (anterior pituitary) 

• Sympathetic stimulation (surgery, stress) → increased ACTH secretion

• Glucocorticoids → inhibit ACTH secretion

o Angiotensin II (renin angiotensin aldosterone system)

o Hyperkalemia


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Andrew Kim