ANP: Factors causing release
Advanced, Organ-Based and Clinical Sciences
Atrial natriuretic peptide (ANP) is a peptide hormone released by cardiac myocytes in response to atrial stretching due to increased extracellular volume/volume overload. This stretch leads to the precursor ProANP being cleaved and released. The ProANP is cleaved by serine proteases to ANP and urodilatin in the kidney. ANP has vasodilatory, diuretic, and natriuretic effects resulting in secondary effects such as reduction of extracellular fluid volume (edema), improved ejection fraction, improved organ perfusion, decreased blood pressure, and increased serum potassium.