ESRD and Neuromuscular Blockade
Advanced, Organ-Based and Clinical Sciences
Elimination half-time is increased by 37%; however, due to increased volume of distribution and plasma clearance in CRF, the duration of action is not significantly prolonged.
Elimination half-time increased by 25-5-%. More extensively metabolized hepatically than rocuronium. Duration of action may be prolonged, but is highly variable. Remember that Vecuronium has a metabolite that is 80% as potent as Vecuronium.
Nearly 100% eliminated by the kidney. Elimination half-time greatly prolonged.
Eliminated by Hoffman elimination. Duration of action is not prolonged.3