Febrile transfusion reaction mechanism

Physiology - Hematologic

Febrile reaction may occur without hemolysis. Recipient antibodies directed against HLA antigens on donor WBCs or platelets are the most common cause, although cytokines released from WBCs of stored products (particularly platelets) may also be a cause. Relatively common in multitransfused or multiparous patients.

Most febrile reactions are treated successfully with acetaminophen and, if necessary, diphenhydramine . Patients should also be treated (eg, with acetaminophen before future transfusions. If a recipient has experienced more than one febrile reaction, special leukoreduction filters are used during future transfusions; many hospitals use prestorage, leukoreduced blood components.

45%

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2014

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45%

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2011

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40%

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2008

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