Fenoldopam: Renal effects

Pharmacology

Fenoldopam is a selective DA1-receptor agonist that has many of the benefits of DA but with little or no alpha or beta adrenoceptor or DA2-receptor agonist activity. Fenoldopam has been shown to exert hypotensive effects characterized by a decrease in peripheral vascular resistance, along with an increase in renal blood flow, diuresis, and natriuresis . It is indicated for patients undergoing cardiac surgery and aortic aneurysm repair, because of its antihypertensive and renal-sparing properties. It is also indicated for patients who have severe hypertension, particularly those with renal impairment.

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2010

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