Hyperbaric O2 seizures: Treatment

Advanced, Clinical Sciences: Anesthesia Procedures, Methods, and Techniques

Hyperbaric oxygen therapy (HBO) is an adjunctive therapy used to treat a number of specific conditions, including acute venous or arterial gas embolism (to reduce the gas bubble size), severe carbon monoxide or cyanide poisoning, to improve wound healing (non-healing ulcers, skin grafts, etc), decompression sickness, and acute traumatic or ischemic injuries (crush, compartment syndrome, etc). The theory behind HBO revolves around Henry’s Law, which states that at a constant temperature and at equilibrium, the amount of gas that dissolves in a liquid is directly proportional to its partial pressure. At sea level, i.e. 1 atm, the dissolved plasma oxygen concentration is 0.3 mL/dL, whereas hyperbaric oxygen delivered at 3 atm results in a dissolved plasma oxygen concentration of 6 mL/dL. 

Management of CNS oxygen toxicity seizures is terminating the HBO therapy session, decreasing the FiO2 to 0.21, giving anticonvulsant therapy, and ultimately supportive care.2

Sources

    Mechem, C.C., Manaker, S. (2016). Hyperbaric Oxygen Therapy. UptoDate.

    Undersea Hyperb Med;2016 Jan-Feb;43(1):21-8

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    Aviat Space Environ Med. 2004 Nov;75(11):995-6

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Answered correctly

2016

Year asked

Author
Kathryn Kirkpatrick, MD