Phenytoin: Neuromusc block effect

Clinical - Neurologic, Pharmacology

“A few drugs may diminish the effects of a nondepolarizing NMBD, including calcium, corticosteroids, and anticonvulsant (phenytoin) drugs.” – Stoelting (Basics of Anesthesia) p143

Interesting, if phenytoin is acutely administered to a phenytoin-naive patient, phenytoin will potentiate the effect of neuromuscular blockade; however, if the patient is on chronic phenytoin, neuromuscular blockers will have a decreased effect.


    Stoelting (Basics of Anesthesia) p143

    Anesth Analg;2005 Feb;100(2):538-44

    [PubMed: 15673889]


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