Succinylcholine: Normal K increase

Advanced, Organ-Based and Clinical Sciences, Pharmacology

Normal muscle releases enough potassium during succinylcholine-induced depolarization to raise serum potassium by ~ 0.5 mEq/L. Although this is usually insignificant in patients with normal baseline potassium levels, it can be life-threatening in patients with preexisting hyperkalemia or those with burn injury, massive trauma, neurological disorders/spinal cord injury (as well as in tetanus, prolonged total body immobilization, ruptured cerebral aneurysm, hemorrhagic shock with metabolic acidosis, and myopathies [eg, Duchenne’s dystrophy])


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